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Research ArticleArticle

REPEATED ACQUISITION AS A BEHAVIORAL BASE LINE FOR STUDYING DRUG EFFECTS

DONALD M. THOMPSON
Journal of Pharmacology and Experimental Therapeutics February 1973, 184 (2) 506-514;
DONALD M. THOMPSON
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Abstract

A new method was developed to study the effects of drugs on learning. In this each subject served as his own control. Pigeons worked for food reinforcenment in a chamber containing three response keys; all three keys were illuminated at the same time by one of four colors. For each session the pigeon's task was to learn a new four-response sequence by pecking the correct key in the presence of each color. After learning (within-session error reduction) had stabilized (40-60 sessions), this base line of repeated acquisition was used to assess the effects of drugs. The dose-effect data indicated that overall accuracy was impaired by phenobarbital, chlordiazepoxide and d-amphetamine arid that the degree of impairment generally increased as a function of dose. In contrast, chlorpromazine did not affect overall accuracy across the dose range tested, although there was a slight error-increasinig effect at the largest doses during the first part of the session. All four drugs increased pausing as a function of dose. Within-session analyses of the effects of the largest doses of phenobarbital, chlondiazepoxide and d-amphetamine indicated that the rate at which errors decreased was less in the drug sessions than in the control sessions.

Footnotes

    • Received April 20, 1972.
    • Accepted October 3, 1972.
  • © 1973 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 184, Issue 2
1 Feb 1973
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Research ArticleArticle

REPEATED ACQUISITION AS A BEHAVIORAL BASE LINE FOR STUDYING DRUG EFFECTS

DONALD M. THOMPSON
Journal of Pharmacology and Experimental Therapeutics February 1, 1973, 184 (2) 506-514;

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Research ArticleArticle

REPEATED ACQUISITION AS A BEHAVIORAL BASE LINE FOR STUDYING DRUG EFFECTS

DONALD M. THOMPSON
Journal of Pharmacology and Experimental Therapeutics February 1, 1973, 184 (2) 506-514;
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