Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

MICROPUNCTURE STUDY OF THE EFFECT OF TRIFLOCIN ON TUBULAR REABSORPTION IN RATS

MICHAEL L. KAUKER
Journal of Pharmacology and Experimental Therapeutics February 1973, 184 (2) 472-480;
MICHAEL L. KAUKER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effects of i.v. infusion of 10 mg/kg b.wt. per hr of triflocin on urine flow, glomerular filtration rate, mean arterial blood pressure, and tubular reabsorption and urinary excrecreation of water, urea, sodium and potassium were evaluated in rats using free flow recollection micropuncture techniques. During the administration of this diuretic agent, blood pressure and glomerular filtration rate were depressed while urine flow increased 20-fold. Proximal tubular net transport of sodium, urea and water were not directly affected by the drug. Addition of urea to the loop of Henle fluid from the collecting duct was observed in nondiuretic control conditions, but intrarenal urea recirculation was abolished during diuresis. Triflocin exerted a major inhibitory action on the distal nephron including the distal convoluted tubule and collecting duct. Here, net transtubular movements of all substances studied were markedly depressed. Urinary excretion of sodium, potassium, urea and water were increased under triflocin action. The diuretic effect of triflocin can be attributed to its direct action at two primary sites: first, inhibition of hypertonic sodium reabsorption by the ascending limb of Henle's loop, and second, suppression of reabsorption in the distal nephron. Its other renal actions are most likely indirect, produced through the maintenance of glomerulotubular balance, medullary washout, increased tubular flow rate or altered tubular concentrations of substances.

Footnotes

    • Received July 20, 1972.
    • Accepted October 2, 1972.
  • © 1973 by The Williams & Wilkins Co.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 184, Issue 2
1 Feb 1973
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
MICROPUNCTURE STUDY OF THE EFFECT OF TRIFLOCIN ON TUBULAR REABSORPTION IN RATS
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

MICROPUNCTURE STUDY OF THE EFFECT OF TRIFLOCIN ON TUBULAR REABSORPTION IN RATS

MICHAEL L. KAUKER
Journal of Pharmacology and Experimental Therapeutics February 1, 1973, 184 (2) 472-480;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

MICROPUNCTURE STUDY OF THE EFFECT OF TRIFLOCIN ON TUBULAR REABSORPTION IN RATS

MICHAEL L. KAUKER
Journal of Pharmacology and Experimental Therapeutics February 1, 1973, 184 (2) 472-480;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics