Abstract
A practical procedure for the routine measurement of gastrointestinal bleeding in rats was developed. The technique is adapted from the chromium-51-labeled erythrocyte method used in humans. In this modification, we used homologous whole blood instead of autologous red cells. Comparison of several nonsteroidal anti-inflammatory agents tested under these conditions indicated that seclazone did not affect gastrointestinal blood loss whereas phenylbutazone and aspirin both induced gastrointestinal bleeding.
Footnotes
- Received April 17, 1972.
- Accepted October 18, 1972.
- © 1973 by The Williams & Wilkins Co.
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