Abstract

A practical procedure for the routine measurement of gastrointestinal bleeding in rats was developed. The technique is adapted from the chromium-51-labeled erythrocyte method used in humans. In this modification, we used homologous whole blood instead of autologous red cells. Comparison of several nonsteroidal anti-inflammatory agents tested under these conditions indicated that seclazone did not affect gastrointestinal blood loss whereas phenylbutazone and aspirin both induced gastrointestinal bleeding.