Abstract
The effect of direct renal nerve stimulation on renal blood flow was determined in anesthetized dogs after administration of phenoxybenzamine (10 mg/kg), bretylium (20 mg/kg), guanethidine (5-10 mg/kg) or reserpine (0.5 mg/kg). Changes in renal blood flow evoked by renal nerve stimulation were measured with an electromagnetic flowmeter. These agents were effective in producing an almost complete blockade of the vasoconstrictor response to nerve stimulation. No increase in renal blood flow during renal nerve stimulation was observed. After administration of the blocking agents, the renal bed was capable of undergoing vasodilatation to prostaglandin E2 (0.2-0.8 µg/min) and acetylehohine (2-20 µg/min) infused into the renal artery. This indicates that further vasodilatation could be elicited after adrenergic blockade. The results suggest that the kidney lacks a sympathetic vasodilator innervation.
Footnotes
- Received September 30, 1971.
- Accepted January 7, 1972.
- © 1972, by The Williams & Wilkins Company
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