Abstract
Intravenous injections of acetaminophen (5 or 10 mg/kg) or sodium salicylate (20 or 40 mg/kg) 30 minutes prior to administration of leukocytic pyrogen, derived from acute peritoneal exudate cells. effectively inhibited the development of fever in response to a wide range of doses of leukocytic pyrogen. Acetaminophen, 2 mg/kg, and sodium salicylate, 10 mg/kg, did not significantly reduce the response to pyrogen injections. In vitro incubations of leukocytes in the presence of acetaminophen (0.1-3.0 mM) or sodium salicylate (0.1-10.0 mM) inhibited neither activation of blood leukocytes by endotoxin nor the release of leukocytic pyrogen from activated blood or peritoneal leukocytes. Inhibition of the pyrogenic effect of leukocytic pyrogen, rather than impairment of the ultimate release of leukocytic pyrogen, accounts for the antipyretic effects of acetaminophen dium salicylate in the cat.
Footnotes
- Received October 14, 1971.
- Accepted January 1, 1972.
- © 1972, by The Williams & Wilkins Company
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