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Research ArticleArticle

EFFECT OF PROPRANOLOL UPON EFFECT THE HEMOGLOBIN-OXYGEN DISSOCIATION CURVE

ROBERT G. PENDLETON, DAVID J. NEWMAN, SHELDON S. SHERMAN, EDWARD G. BRANN and WILLIAM E. MAYA
Journal of Pharmacology and Experimental Therapeutics March 1972, 180 (3) 647-656;
ROBERT G. PENDLETON
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DAVID J. NEWMAN
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SHELDON S. SHERMAN
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EDWARD G. BRANN
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WILLIAM E. MAYA
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Abstract

Propranolol (1-5 x 10-4 M) was found to shift the hemoglobin-oxygen dissociation curve of human erythrocytes significantly to the right; the mean p50 was increased in various studies by 6 to 8 mm Hg. The dissociation curve was measured in vitro on freshly obtained, washed red blood cells previously incubated for 90 minutes in physiological buffer (pH 7.4, T = 37°C) which contained the test compound. Concomitant with shifting the curve, propranolol also altered the morphology of the red blood cells and reduced the hematocrit. d-Propranolol was more effective than the l-form in shifting the curve and INPEA, MJ 1999 and Kö 592 were ineffective at 5 x 10-4 M, indicating the effect was not beta receptor mediated. Propranolol did not affect the dissociation curve of dialyzed hemoglobin or of erythrocytes obtained from out-dated blood. Biochemically, the drug significantly decreased the erythrocyte content of 2,3-diphosphoglyceric acid and adenosine triphosphate and inhibited glucose utilization by ∼60%. The onset of propranolol action on cellular morphology and the dissociation curve was essentially instantaneous and peaked within approximately 20 minutes which suggests these effects may be membrane mediated.

Footnotes

    • Received July 12, 1971.
    • Accepted November 27, 1971.
  • © 1972 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 180, Issue 3
1 Mar 1972
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Research ArticleArticle

EFFECT OF PROPRANOLOL UPON EFFECT THE HEMOGLOBIN-OXYGEN DISSOCIATION CURVE

ROBERT G. PENDLETON, DAVID J. NEWMAN, SHELDON S. SHERMAN, EDWARD G. BRANN and WILLIAM E. MAYA
Journal of Pharmacology and Experimental Therapeutics March 1, 1972, 180 (3) 647-656;

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Research ArticleArticle

EFFECT OF PROPRANOLOL UPON EFFECT THE HEMOGLOBIN-OXYGEN DISSOCIATION CURVE

ROBERT G. PENDLETON, DAVID J. NEWMAN, SHELDON S. SHERMAN, EDWARD G. BRANN and WILLIAM E. MAYA
Journal of Pharmacology and Experimental Therapeutics March 1, 1972, 180 (3) 647-656;
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