Abstract
Strain differences in response of aggregated Swiss Webster and BDF1 mice to d-amphetamine were investigated at three environmental temperatures of 19, 23 and 27°C. At 19°C the Swiss Webster strain of mice exhibited the aggregate toxicity to d-amphetamine whereas the BDF strain did not. An increase in ambient room temperature resulted in the appearance of amphetamine aggregate toxicity in the BDF1 strain. The toxicity also increased in the Swiss Webster strain at the higher room temperatures. The strain difference in mortality at 19°C was unrelated to brain levels or metabolism of d-amphetamine. Although hyperthermia was noted at all temperatures studied, the BDF strain responded to a lesser degree than the Swiss Webster strain. An increase in room temperature resulted in an increase in amphetamine-induced hyperthermia. These results indicate that the magnitude of this pharmacogenetic difference is dependent on room temperature, that pharmacokinetic factors are not involved in the difference and that a thermoregulatory difference between the strains is a factor in the strain difference in toxicity.
Footnotes
- Received February 22, 1971.
- Accepted November 8, 1971.
- © 1972 by The Williams & Wilkins Co.
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