Abstract
Administration of 6-OH-dopamine daily for two days causes a nearly complete depletion of endogenous norepinephrine and a persistent, although not total, loss of activity of dopamine-β-hydroxylase from the heart. In adrenal glands, 6-OH-dopamine administration increases the activity both of tyrosine hydroxylase and dopainine-β-hydroxylase without affecting catecholamine levels. In both normally innervated and decentralized sympathetic ganglia, administration of 6-OH-dopamine causes no change in tyrosine hydroxylase activity and a long-lasting 50% decrease in dopamine-β-hydroxylase activity. Pretreatment with 6-OH-dopamine prevents reserpine-induced. increases in the activity of these enzymes in ganglia. A similar effect is also produced by surgical section of the postganglionic axons of the superior cervical ganglion.
Footnotes
- Received February 9, 1971.
- Accepted May 24, 1971.
- © 1971 by The Williams & Wilkins Co.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|