Abstract
Administration of trans-5-amino-3[2-(5-nitro-2-furyl)-vinyl]-1,2,4-oxadiazole (SQ 18,506) to rhesus monkeys infected with either Schistosoma mansoni or Schistosoma japonicum resulted in marked chemotherapeutic activity and no apparent host toxicity. The number of worms recovered from the treated monkeys was reduced considerably. The surviving worms were stunted. Damage to these worms was revealed also by a very marked decrease in the number of eggs present in the tissues of the host and in the feces, by frequent abnormalities in the female reproductive system and by decreased glycogen levels in the males.
Footnotes
- Received December 18, 1970.
- Accepted April 4, 1971.
- © 1971 by The Williams & Wilkins Co.
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