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Research ArticleArticle

STIMULATION OF SEROTONIN SYNTHESIS BY LITHIUM

JORGE PEREZ-CRUET, ALESSANDRO TAGLIAMONTE, PAOLA TAGLIAMONTE and GIAN L. GESSA
Journal of Pharmacology and Experimental Therapeutics August 1971, 178 (2) 325-330;
JORGE PEREZ-CRUET
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ALESSANDRO TAGLIAMONTE
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PAOLA TAGLIAMONTE
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GIAN L. GESSA
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Abstract

Repeated administrations of lithium salts (Li2CO3 or LiCl, 60 and 85 mg/kg, respectively, twice a day for five days) to rats increased brain 5-hydroxyindoleacetic acid (5-HIAA) by about 80% and brain serotonin by 15 to 20%. The changes were not due to an inhibition of 5-HIAA transport from brain, but to an increase in the rate of synthesis of brain serotonin. Rate of serotonin synthesis was measured by multiplying the rate constant of 5-HIAA decline, after inhibition of monoamine oxidase, by the steady-state level of 5-HIAA. The calculation indicated that lithium increased the synthesis rate of brain serotonin by about 80%. Moreover, chronic treatment with lithium salts also increased the levels of brain tryptophan by about 70%, suggesting that this could be the mechanism by which lithium stimulates serotonin synthesis.

Footnotes

    • Received July 23, 1970.
    • Accepted April 4, 1971.
  • © 1971 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 178, Issue 2
1 Aug 1971
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Research ArticleArticle

STIMULATION OF SEROTONIN SYNTHESIS BY LITHIUM

JORGE PEREZ-CRUET, ALESSANDRO TAGLIAMONTE, PAOLA TAGLIAMONTE and GIAN L. GESSA
Journal of Pharmacology and Experimental Therapeutics August 1, 1971, 178 (2) 325-330;

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Research ArticleArticle

STIMULATION OF SEROTONIN SYNTHESIS BY LITHIUM

JORGE PEREZ-CRUET, ALESSANDRO TAGLIAMONTE, PAOLA TAGLIAMONTE and GIAN L. GESSA
Journal of Pharmacology and Experimental Therapeutics August 1, 1971, 178 (2) 325-330;
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