Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

THE FATE OF INTRACISTERNALLY ADMINISTERED NOREPINEPHRINE-3H IN THE BRAIN AND SPINAL CORD OF THE RABBIT

J. P. CHALMERS and R. J. WURTMAN
Journal of Pharmacology and Experimental Therapeutics July 1971, 178 (1) 8-19;
J. P. CHALMERS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. J. WURTMAN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Norepinephrine-3H was introduced into the cerebroventricular system of the rabbit by a simple intracisternal approach that is described in detail. The size of the rabbit brain and spinal cord permitted ready investigation of the fate of injected norepinephrine-3H not only in the whole brain and five of its subdivisions (telencephalon, hypothalamus, midbrain, medulla-pons and cerebellum) but also in three regions of the spinal cord (cervical, thoracolumbar and lumbosacral). The initial distribution of injected norepinephrine-3H was not as closely correlated with the distribution of endogenous norepinephrine as has been reported for the rat. Instead, the distance of each region from the injection site appeared to be the major factor determining the relative uptake. For example, uptake was progressively lower in the cervical, thoracolumbar and lumbosacral segments of the spinal cord even though these three areas contain similar concentrations of endogenous norepinephrine. There was a multiphasic decline in norepinephrine-3H concentration in whole brain, whole spinal cord and in each of the brain and cord regions examined. Initial rapid disappearance in the first hour was followed by a slower, single-exponential decay phase observed between 6 and 12 hours after norepinephrine-3H injection. The half-lives for this second phase of norepinephrine-3H disappearance were longest in the hypothalamus, thoracolumbar cord and midbrain and shortest in the cerebellum, medulla-pons and cervical cord.

Footnotes

    • Received November 2, 1970.
    • Accepted April 2, 1971.
  • © 1971, by The Williams & Wilkins Company

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 178, Issue 1
1 Jul 1971
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
THE FATE OF INTRACISTERNALLY ADMINISTERED NOREPINEPHRINE-3H IN THE BRAIN AND SPINAL CORD OF THE RABBIT
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

THE FATE OF INTRACISTERNALLY ADMINISTERED NOREPINEPHRINE-3H IN THE BRAIN AND SPINAL CORD OF THE RABBIT

J. P. CHALMERS and R. J. WURTMAN
Journal of Pharmacology and Experimental Therapeutics July 1, 1971, 178 (1) 8-19;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

THE FATE OF INTRACISTERNALLY ADMINISTERED NOREPINEPHRINE-3H IN THE BRAIN AND SPINAL CORD OF THE RABBIT

J. P. CHALMERS and R. J. WURTMAN
Journal of Pharmacology and Experimental Therapeutics July 1, 1971, 178 (1) 8-19;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics