Abstract
The renal effects of known uricosuric agents have been studied by standard clearance techniques in male chimpanzees. Probenecid, sulfinpyrazone and zoxazolaznine were orally active. Low doses of probenecid elicited a modest uricosuric effect suggesting that the renal transport of urate in this species may be more sensitive than that which obtains in man. Salicylate and carinamide were uricosuric; iodopyracet at high loads was also strongly uricosuric. Chlorothiazide administered i.v. produced a very transient increase in uric acid excretion similar to that seen in man.
Footnotes
- Received December 31, 1970.
- Accepted March 1, 1971.
- © 1971 by The Williams & Wilkins Co.
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