Abstract

The renal effects of known uricosuric agents have been studied by standard clearance techniques in male chimpanzees. Probenecid, sulfinpyrazone and zoxazolaznine were orally active. Low doses of probenecid elicited a modest uricosuric effect suggesting that the renal transport of urate in this species may be more sensitive than that which obtains in man. Salicylate and carinamide were uricosuric; iodopyracet at high loads was also strongly uricosuric. Chlorothiazide administered i.v. produced a very transient increase in uric acid excretion similar to that seen in man.