Abstract
Rabbits treated for 13 weeks with large doses of known dimethyl sulfoxide metabolites did not develop the lenticular changes associated with dimethyl sulfoxide treatment. No hydration of the lens or other tissues could be detected in animals treated p.o. with dimethyl sulfoxide for 24 weeks. Dimethyl sulfoxide was shown to react with glutathione as well as eye lens proteins to yield dimethyl sulfide. A mechanism for dimethyl sulfoxide toxicity to the rabbit lens is postulated.
Footnotes
- Received September 17, 1970.
- Accepted February 25, 1971.
- © 1971 by The Williams & Wilkins Co.
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