Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

HEMODYNAMIC EFFECTS OF NITROGLYCERIN AND AMYL NITRITE IN THE CONSCIOUS DOG

ROBERT A. O'ROURKE, VERNON S. BISHOP, PETER A. KOT and JOHN P. FERNANDEZ
Journal of Pharmacology and Experimental Therapeutics May 1971, 177 (2) 426-432;
ROBERT A. O'ROURKE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
VERNON S. BISHOP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
PETER A. KOT
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JOHN P. FERNANDEZ
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The instantaneous hemodynamic effects of i.v. nitroglycerin (25 µg/kg) and amyl nitrite inhalation were compared in seven conscious mongrel dogs two weeks or more after implantation of electromagnetic flow probes around the ascending aorta and the insertion of polyvinyl catheters into the right atrium, left atrium and ascending aorta. The hemodynamic effects of the two drugs were identical. The decrease in mean arterial pressure, stroke volume, and mean atrial pressures and the increase in heart rate and cardiac output were all statistically significant. In two conscious dogs continuous measurements of transverse internal left ventricular diameter were recorded by a sonomicrometer before and during drug administration. The end-diastolic diameter, the end-systolic diameter and the stroke excursion (end-diastolic minus end-systolic diameter) decreased from control values with both nitroglycerin and amyl nitrite (P < .05). In two dogs the heart rate was controlled by a right atrial bipolar pacemaker catheter and the experiment was repeated on four occasions with each drug. With the heart rate controlled at 210 beats/min, both nitroglycerin and amyl nitrite produced an increment rather than a decrease in stroke volume, and an increase in stroke excursion, despite a decrease in end- diastolic diameter. This study indicates that rapidly administered amyl nitrite and nitroglycerin produce identical hemodynamic changes which result from vasodilatation of resistance and capacitance vessels and the baroreceptor reflex response to a sudden decrease in mean arterial pressure.

Footnotes

    • Received October 27, 1970.
    • Accepted January 6, 1971.
  • © 1971 by The Williams & Wilkins Co.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 177, Issue 2
1 May 1971
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
HEMODYNAMIC EFFECTS OF NITROGLYCERIN AND AMYL NITRITE IN THE CONSCIOUS DOG
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

HEMODYNAMIC EFFECTS OF NITROGLYCERIN AND AMYL NITRITE IN THE CONSCIOUS DOG

ROBERT A. O'ROURKE, VERNON S. BISHOP, PETER A. KOT and JOHN P. FERNANDEZ
Journal of Pharmacology and Experimental Therapeutics May 1, 1971, 177 (2) 426-432;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

HEMODYNAMIC EFFECTS OF NITROGLYCERIN AND AMYL NITRITE IN THE CONSCIOUS DOG

ROBERT A. O'ROURKE, VERNON S. BISHOP, PETER A. KOT and JOHN P. FERNANDEZ
Journal of Pharmacology and Experimental Therapeutics May 1, 1971, 177 (2) 426-432;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Prolonged Inhibition ofO 6-Methylguanine DNA Methyltransferase in Human Tumor Cells by O 6-Benzylguanine In Vitro and In Vivo
  • Reduction of 5-Hydroxytryptamine (5-HT)1A-Mediated Temperature and Neuroendocrine Responses and 5-HT1A Binding Sites in 5-HT Transporter Knockout Mice
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics