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Research ArticleArticle

NICOTINE-INDUCED DEPOLARIZATION AND STIMULATION OF POTASSIUM EFFLUX IN STRIATED MUSCLE

EDWARD G. HENDERSON and JOHN C. HANCOCK
Journal of Pharmacology and Experimental Therapeutics May 1971, 177 (2) 377-388;
EDWARD G. HENDERSON
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JOHN C. HANCOCK
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Abstract

The influence of nicotine on potassium (42K) exchange in denervated frog sartorius and rat extensor digitorum longus muscles was examined. Nicotine (0.005-0.2 mM) did not alter the uptake of 42K in any of the muscles tested. Efflux was significantly increased during the first one to five minutes of nicotine exposure and returned to normal monotonically within an hour in both types of denervated muscle as well as in the innervated frog sartorius muscle. After removal of nicotine, there was a long period (>1.0 hour) during which 42K efflux was decreased 20 to 50% below control values. The time course of 42K efflux stimulation paralleled the time course of muscle cell membrane depolarization. Both the nicotine-induced depolarization and stimulation of 42K efflux were blocked by prior administration of d-tubocurarine and, therefore, were probably initiated by an interaction of nicotine with chemosensitive sites on the muscle cells. The decreased rate of 42K efflux after nicotine removal was not blocked when d-tubocurarine was added immediately after exposure to nicotine. Conduction in sartorius muscle cells was not blocked by low concentrations of nicotine (<0.06 mM) and action potentials recorded during the peak of depolarization were followed by a "late positive afterpotential" of long duration (>150 msec). The magnitude of the late positive afterpotential was increased by reducing the potassium concentration of the bathing medium.

Footnotes

    • Received August 31, 1970.
    • Accepted January 15, 1971.
  • © 1971 by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 177, Issue 2
1 May 1971
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Research ArticleArticle

NICOTINE-INDUCED DEPOLARIZATION AND STIMULATION OF POTASSIUM EFFLUX IN STRIATED MUSCLE

EDWARD G. HENDERSON and JOHN C. HANCOCK
Journal of Pharmacology and Experimental Therapeutics May 1, 1971, 177 (2) 377-388;

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Research ArticleArticle

NICOTINE-INDUCED DEPOLARIZATION AND STIMULATION OF POTASSIUM EFFLUX IN STRIATED MUSCLE

EDWARD G. HENDERSON and JOHN C. HANCOCK
Journal of Pharmacology and Experimental Therapeutics May 1, 1971, 177 (2) 377-388;
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