Abstract
Diphenylthiohydantoin exhibits a spectrum of pharmacologic activity similar to that of diphenylhydantoin in the cat spinal cord. In addition to evidence of neurodepression, however, the former compound enhances polysynaptic discharges and depresses presynaptic inhibition in doses that do not influence monosynaptic reflex spike amplitude. Diphenylthiohydantoin enhances dorsal root potentials when evoked by dorsal root stimulation, but not when evoked by stimulation of the nerve to the posterior biceps-semitendinosus. The effects of diphenylthiohydantoin on the cat spinal cord, unlike those of diphenylhydantoin, are rapid in onset and short in duration.
Footnotes
- Received November 23, 1970.
- Accepted January 30, 1971.
- © 1971 by The Williams & Wilkins Co.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.