Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

EFFECT OF DACTINOMYCIN ON THE ACUTE TOXICITY AND BRAIN UPTAKE OF MORPHINE

HORACE H. LOH, FU-HSIUNG SHEN and E. LEONG WAY
Journal of Pharmacology and Experimental Therapeutics May 1971, 177 (2) 326-331;
HORACE H. LOH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
FU-HSIUNG SHEN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. LEONG WAY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

After 0.5 mg/kg i.p. of dactinomycin (actinomycin D, Cosmegen) the s.c. LD50 of morphine in mature mice was 460 mg/kg whereas without dactinomycin it was 800 mg/kg. Estimation of brain concentrations of morphine indicated that the levels of morphine in dactinomycin-treated animals were appreciably higher than those in nontreated animals. Two hours after morphine administration dactinomycin-treated animals exhibited a mean brain level of morphine approximately twice that of the control group. In immature mice which had not developed a blood-brain barrier to morphine, dactinomycin did not alter the LD50 of morphine nor the distribution of morphine in the brain. Dactinomycin also did not influence the lethality of heroin in adult mice. In the adult rat, dactinomycin also enhanced brain uptake of morphine. After treatment with dactinomycin, a higher brain/blood ratio of morphine was obtained without any alteration in the plasma binding of morphine. It appears, therefore, that dactinomycin enhances toxicity to morphine at least in part by increasing brain permeability to morphine.

Footnotes

    • Received November 12, 1970.
    • Accepted January 14, 1970.
  • © 1971 by The Williams & Wilkins Co.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 177, Issue 2
1 May 1971
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
EFFECT OF DACTINOMYCIN ON THE ACUTE TOXICITY AND BRAIN UPTAKE OF MORPHINE
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

EFFECT OF DACTINOMYCIN ON THE ACUTE TOXICITY AND BRAIN UPTAKE OF MORPHINE

HORACE H. LOH, FU-HSIUNG SHEN and E. LEONG WAY
Journal of Pharmacology and Experimental Therapeutics May 1, 1971, 177 (2) 326-331;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

EFFECT OF DACTINOMYCIN ON THE ACUTE TOXICITY AND BRAIN UPTAKE OF MORPHINE

HORACE H. LOH, FU-HSIUNG SHEN and E. LEONG WAY
Journal of Pharmacology and Experimental Therapeutics May 1, 1971, 177 (2) 326-331;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Meeting Report for the ASPET–Ray Fuller Symposium: Cellular Mechanisms and Novel Strategies for Pain Control
  • Antinociceptive Properties of Fenfluramine, a Serotonin Reuptake Inhibitor, in a Rat Model of Neuropathy
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics