Abstract

Tricyclic psychotropic amines induce hemolysis in vitro. Heterocydlic compounds usually are less active than the corresponding hydrocarbons. The length of a side chain and its relative polarization determine the hemolytic potency of a compound. Nonfused ring structures are hemolytically inactive. Several biologic and physicochemical properties are closely correlated with the hemolytic potency of the tricyclic amines. The tranquilizing potency rises exponentially with increasing lysis index, a measurement of the relative hemolytic potency. The lysis index also correlates closely with the adenosine triphosphatase inhibition, the surface activity and the chloroform/0.1 N hydrochloric acid partition coefficient of phenothiazines.