Abstract
Catechol-O-methyltransferase, histamine-N-methyltransferase and a methanol-forming enzyme were identified in the red blood cells of humans and a variety of mammalian species. The properties of the transferase enzymes are described with respect to distribution in blood, co-factor requirements, products formed, species distribution and substrate specificity. The presence of the transferase enzyme in an easily accessible tissue in man makes possible a study of changes in these enzymes in different physiologic states, drug treatments and diseases.
Footnotes
- Received August 31, 1970.
- Accepted November 23, 1970.
- © 1971 by The Williams & Wilkins Co.
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