Abstract
The vasodilatory effect of ethacrynic acid (EA) was studied in the hindlimb of anesthetized anephric dogs, perfused with a constant inflow of arterial blood. After i.v. EA there was a reduction in hindlimb vascular resistance both in the presence and absence of sympathetic innervation to the limb and in the presence of pharmacologic blockade of alpha or beta adrenergic, cholinergic or histaminic receptors. A dose-response relationship was demonstrated as the dose of EA was increased from 0.25 to 10.0 mg/kg. The maximal effect at all dose levels was delayed, suggesting an intermediate step in the mechanism of action. Studies were made of the hindlimb vascular response to anoxia produced by 30-second periods of stop-flow. After EA there was prolongation of the time to recover from the reactive hyperemia and an increased vasodilatory response to the anoxic period, suggesting that EA interfered with the ability of vascular smooth muscle to recover from anoxic work.
Footnotes
- Received March 30, 1970.
- Accepted October 24, 1970.
- © 1971 by The Williams & Wilkins Co.
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