Abstract
L 3428, a benzofuran derivative, was tested for its effect on various resting cardiovascular parameters and compared to glyceryl trinitrate, pentaerythritol tetranitrate, dipyridamole and propranolol. L 3428 increased coronary blood flow and coronary sinus oxygen content and decreased left ventricular work, mean arterial blood pressure, left ventricular oxygen consumption, coronary vascular resistance, total peripheral resistance and heart rate; left ventricular output was either unchanged or slightly increased. The nitrates (glyceryl trinitrate and pentaerythritol tetranitrate) produced effects that were qualitatively similar. That is, coronary blood flow, left ventricular output and heart rate increased whereas left ventricular work, mean arterial blood pressure, coronary vascular resistance and total peripheral resistance decreased. Dipyridamole increased coronary blood flow and decreased calculated left ventricular oxygen consumption, coronary vascular resistance and total peripheral resistance; alight alterations occurred in left ventricular work, heart rate, mean arterial blood pressure and left ventricular output. Propranolol decreased coronary blood flow, left ventricular oxygen consumption, mean arterial blood pressure, heart rate and left ventricular output; coronary vascular resistance and total peripheral resistance increased. The pharmacologic findings are discussed in light of current concepts that an antianginal drug should reduce myocardial oxygen requirements and improve myocardial oxygen supply.
Footnotes
- Received December 10, 1969.
- Accepted October 23, 1970.
- © 1971 by The Williams & Wilkins Co.
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