Abstract
In isolated rat left ventricular trabeculae carneae muscle preparations, ketamine doses greater than 2.5 x 10-4 M depressed Vmax and PO of the force velocity relation as well as isometric developed tension, the rate of tension development and other indices of contractile performance. Although no changes in resting compliance were observed, the highest ketamine doses increased series elastic extension, chronaxie, rheobase and the refractory and latent periods. An antiarrhythmic effect of ketamine was observed.
Footnotes
- Received March 16, 1970.
- Accepted July 12, 1970.
- © 1970 by The Williams & Wilkins Co.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement