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Research ArticleArticle

DAILY RHYTHM IN THE ACCUMULATION OF BRAIN CATECHOLAMINES SYNTHESIZED FROM CIRCULATING H3-TYROSINE

MICHAEL J. ZIGMOND and RICHARD J. WURTMAN
Journal of Pharmacology and Experimental Therapeutics April 1970, 172 (2) 416-422;
MICHAEL J. ZIGMOND
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RICHARD J. WURTMAN
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Abstract

The accumulation of H-catecholamines in brain was measured in rats given i. p. H3-tyrosine (H3-TYR). In animals injected at the same time of day, brain H3-TYR reached a peak within 10 minutes of injection and remained at this level for at least 120 minutes. Brain H3-catecholamine content was highest 60 minutes after injection. However, H3-catecholamine content corrected for the specific activity of H3-TYR during the accumulation period attained its peak within 10 minutes of the injection and remained at this level for the next two hours; this suggests that the newly synthesized catecholamine equilibrates rapidly with one of several brain pools. Animals maintained under light for 12 hr/day received H3-TYR at the middle or end of the daily light or dark period and were killed after 3 or 60 minutes. The accumulation of H3-catecholamine was significantly higher in the middle of the light period than in the dark period when correction was made for fluctuations in the specific activity of tyrosine.

Footnotes

    • Received May 19, 1969.
    • Accepted November 3, 1969.
  • © 1970, by The Williams & Wilkins Co.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 172, Issue 2
1 Apr 1970
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Research ArticleArticle

DAILY RHYTHM IN THE ACCUMULATION OF BRAIN CATECHOLAMINES SYNTHESIZED FROM CIRCULATING H3-TYROSINE

MICHAEL J. ZIGMOND and RICHARD J. WURTMAN
Journal of Pharmacology and Experimental Therapeutics April 1, 1970, 172 (2) 416-422;

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Research ArticleArticle

DAILY RHYTHM IN THE ACCUMULATION OF BRAIN CATECHOLAMINES SYNTHESIZED FROM CIRCULATING H3-TYROSINE

MICHAEL J. ZIGMOND and RICHARD J. WURTMAN
Journal of Pharmacology and Experimental Therapeutics April 1, 1970, 172 (2) 416-422;
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