Abstract
The entry of total C14O2 and Cl36 from blood into cerebrospinal fluid (CSF) was studied in cats with ventriculo-cisternal perfusion both before and after the administration of acetazolamide, a carbonic anhydrase inhibitor. It was found that the normal animal accumulates total C14O2, by hydration of CO2 to HCO3-, at 5 times the rate of the inhibited animal, a difference that cannot be explained by changes in CSF production alone. The rate of entry of Cl36 in the normal animal was about twice that found in the inhibited animal, a change that was the same as that in CSF formation rate. It thus appears that both HCO3- formation and C1- transport into the CSF depend upon catalytic hydration of CO2, a process which may be important in the physiologic regulation of CSF acid-base equilibria and fluid production.
Footnotes
- Received October 10, 1969.
- Accepted December 11, 1969.
- © 1970, by The Williams & Wilkins Co.
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