Abstract
ICI 54,450, a new nonsteroidal anti-inflammatory agent undergoes metabolism in rats and dogs involving NIH shift migration of the chioro substituent. In monkeys no metabolites of ICI 54,450 other than urinary acyl glucuronides were detected. Serum of all species contained solely unchanged ICI 54,450. The metabolic hydroxylation of ICI 54,450 has been reproduced in part by treatment with pertrifiuoracetic acid.
Footnotes
- Received March 17, 1969.
- Accepted October 2, 1969.
- © 1970, by The Williams & Wilkins Company
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