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Research ArticleArticle

NARCOTIC-ANTAGONIST ANALGESICS: INTERACTIONS WITH CHOLINERGIC SYSTEMS

LOUIS S. HARRIS, WILLIAM L. DEWEY, JOHN F. HOWES, JAMES S. KENNEDY and HARRY PARS
Journal of Pharmacology and Experimental Therapeutics September 1969, 169 (1) 17-22;
LOUIS S. HARRIS
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WILLIAM L. DEWEY
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JOHN F. HOWES
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JAMES S. KENNEDY
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HARRY PARS
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Abstract

It has been found that the previously inactive narcoticantagonist analgesics become active in the mouse tail-flick test in the presence of physostigmine. Physostigmine itself and the centrally acting cholinergic agent oxotremorine are potent inhibitors of this reflex. Naloxone, a pure narcotic antagonist, can block the effects of physostigmine and oxotremorine. The narcotic-antagonist analgesics also block the contractions of the isolated coaxially stimulated guinea-pig ileum. In a wide variety of narcotic antagonists, a high correlation has been found between the activity of these compounds in this test procedure and their potency as analgesics in man. These results are discussed in support of the hypothesis that cholinergic systems may be involved in the analgesic action of these drugs.

Footnotes

    • Received August 14, 1968.
    • Accepted May 9, 1969.
  • © 1969, by The Williams & Wilkins Company

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Journal of Pharmacology and Experimental Therapeutics
Vol. 169, Issue 1
1 Sep 1969
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Research ArticleArticle

NARCOTIC-ANTAGONIST ANALGESICS: INTERACTIONS WITH CHOLINERGIC SYSTEMS

LOUIS S. HARRIS, WILLIAM L. DEWEY, JOHN F. HOWES, JAMES S. KENNEDY and HARRY PARS
Journal of Pharmacology and Experimental Therapeutics September 1, 1969, 169 (1) 17-22;

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Research ArticleArticle

NARCOTIC-ANTAGONIST ANALGESICS: INTERACTIONS WITH CHOLINERGIC SYSTEMS

LOUIS S. HARRIS, WILLIAM L. DEWEY, JOHN F. HOWES, JAMES S. KENNEDY and HARRY PARS
Journal of Pharmacology and Experimental Therapeutics September 1, 1969, 169 (1) 17-22;
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