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Research ArticleArticle

EFFECT OF STEROID HORMONES ON THE PARATHYROID HORMONE DOSE-RESPONSE CIJRVE

L. E. MAGARGAL, H. MAGARGAL and M. M. REIDENBERG
Journal of Pharmacology and Experimental Therapeutics September 1969, 169 (1) 138-141;
L. E. MAGARGAL
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H. MAGARGAL
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M. M. REIDENBERG
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Abstract

The interaction between various steroid hormones and parathyroid hormone was studied by observing the effect of each of these steroids on the parathyroid hormone dose-response curve in thyroparathyroidectomized rats. Methylprednisolone, estradiol or testosterone was given to rats for 48 hours prior to injection of parathyroid hormone. Increase in serum calcium six hours after parathyroid hormone was defined as the response. The steroids lowered the initial serum calcium taken prior to parathyroid hormone. Methylprednisolone inhibited the response at all dose levels of parathyroid hormone. Estradiol and testosterone enhanced the response to low doses of parathyroid hormone and inhibited the response to high doses.

Footnotes

    • Received March 21, 1969.
    • Accepted May 24, 1969.
  • © 1969, by The Williams & Wilkins Company

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Journal of Pharmacology and Experimental Therapeutics
Vol. 169, Issue 1
1 Sep 1969
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Research ArticleArticle

EFFECT OF STEROID HORMONES ON THE PARATHYROID HORMONE DOSE-RESPONSE CIJRVE

L. E. MAGARGAL, H. MAGARGAL and M. M. REIDENBERG
Journal of Pharmacology and Experimental Therapeutics September 1, 1969, 169 (1) 138-141;

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Research ArticleArticle

EFFECT OF STEROID HORMONES ON THE PARATHYROID HORMONE DOSE-RESPONSE CIJRVE

L. E. MAGARGAL, H. MAGARGAL and M. M. REIDENBERG
Journal of Pharmacology and Experimental Therapeutics September 1, 1969, 169 (1) 138-141;
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