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Research ArticleArticle

INHIBITION OF TISSUE HISTAMINE FORMATION BY DECABORANE

MIGUEL A. MEDINA, JUANITA H. LANDEZ and LLOYD L. FOSTER
Journal of Pharmacology and Experimental Therapeutics September 1969, 169 (1) 132-137;
MIGUEL A. MEDINA
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JUANITA H. LANDEZ
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LLOYD L. FOSTER
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Abstract

The effect of decaborane (B10H14) upon tissue levels of histamine and histidine decarboxylase activity was studied. In rats decaborane reduced the levels of histamine in kidney, liver, stomach and urine but had no effect on heart. Brain histamine was also diminished by 50% in mice, rats, guinea pigs and rabbits. Histamine depletion was still apparent in rat brain one week after a single injection of decaborane (15 mg/kg), whereas depletion of rat stomach histamine lasted only 48 hours. It was suggested that this may be due to a difference in the turnover rate of histamine in the two tissues. Histidine decarboxylase activity (rat glandular stomach) was strongly inhibited after injection of decaborane. Other drugs tested had no effect on rat brain histamine. The data suggest that decaborane may depress histamine levels by inhibiting histidine decarboxylase and that brain histamine may exist in different metabolic pools.

Footnotes

    • Received February 11, 1969.
    • Accepted May 26, 1969.
  • © 1969, by The Williams & Wilkins Company

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Journal of Pharmacology and Experimental Therapeutics
Vol. 169, Issue 1
1 Sep 1969
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Research ArticleArticle

INHIBITION OF TISSUE HISTAMINE FORMATION BY DECABORANE

MIGUEL A. MEDINA, JUANITA H. LANDEZ and LLOYD L. FOSTER
Journal of Pharmacology and Experimental Therapeutics September 1, 1969, 169 (1) 132-137;

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Research ArticleArticle

INHIBITION OF TISSUE HISTAMINE FORMATION BY DECABORANE

MIGUEL A. MEDINA, JUANITA H. LANDEZ and LLOYD L. FOSTER
Journal of Pharmacology and Experimental Therapeutics September 1, 1969, 169 (1) 132-137;
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