Abstract
The suggestion that haloperidol is a dopamineblocking agent was investigated by determining the effects of the neuroleptic agent on the renal and mesenteric vasodilation produced in the dog by i.a. injections of dopamine. Doseresponse curves of dopamine, bradykinin and isoproterenol were constructed before and after injection of haloperidol. Prior injections of haloperidol in the renal artery (2 x 10-7 mol) and in the mesenteric artery (2.7 x 10-6 mol) attenuated the effects of dopamine to a significantly greater degree than that of the other agents. By combining 1.4 x 10-7 mol of haloperidol (0.054 mg) with varying doses of the vasodilators, it was possible to demonstrate attenuation of dopamine-induced renal vasodilation without significantly affecting the effects of isoproterenol or bradykinin. The renal vasodilating action of Epinine (N-methyldopamine) was also attenuated by haloperidol. The demonstration that haloperidol selectively attenuates the vasodilating actions of dopamine supports the concept that dopamine acts on a specific receptor in the renal and mesenteric vascular beds.
Footnotes
- Received January 18, 1969.
- Accepted April 23, 1969.
- © 1969 by The Williams & Wilkins Co.
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