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Research ArticleArticle

THE METABOLISM OF TOLBUTAMIDE IN RAT LIVER

HUEY G. McDANIEL, HELEN PODGAINY and RUBIN BRESSLER
Journal of Pharmacology and Experimental Therapeutics May 1969, 167 (1) 91-97;
HUEY G. McDANIEL
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HELEN PODGAINY
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RUBIN BRESSLER
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Abstract

Incubation of tritiumlabeled tolbutamide with a 9000x g rat liver supernatant resulted in a conversion to metabolically inactive carboxytolbutamide. The incubation of tolbutamide with rat liver microsomes resulted in the formation of hydroxytolbutamide. This conversion was inhibited by SKF 525-A. The oxidation of hydroxytolbutamide was carried out by the rat liver 100,000 x g supernatant. Alcohol dehydrogenase also catalyzed the oxidation of hydroxytolbutamide, and the product of this reaction was oxidized by both xanthine oxidase and aldehyde dehydrogenase. Carboxytolbutamide was formed from the oxidation of hydroxytolbutamide catalyzed by alcohol dehydrogenase and aldehyde dehydrogenase.

Footnotes

    • Received December 27, 1967.
    • Accepted January 10, 1969.
  • © 1969, by The Williams & Wilkins Company

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Journal of Pharmacology and Experimental Therapeutics
Vol. 167, Issue 1
1 May 1969
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Research ArticleArticle

THE METABOLISM OF TOLBUTAMIDE IN RAT LIVER

HUEY G. McDANIEL, HELEN PODGAINY and RUBIN BRESSLER
Journal of Pharmacology and Experimental Therapeutics May 1, 1969, 167 (1) 91-97;

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Research ArticleArticle

THE METABOLISM OF TOLBUTAMIDE IN RAT LIVER

HUEY G. McDANIEL, HELEN PODGAINY and RUBIN BRESSLER
Journal of Pharmacology and Experimental Therapeutics May 1, 1969, 167 (1) 91-97;
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