Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

ANTAGONISM OF GANGLIONIC STIMULANTS BY α,ά-BIS-(DIMETHYLAMMONIUMACETALDEHYDE DIETHYLACETAL)-p,p''-DIACETYLBIPHENYL BROMIDE (DMAE)

S. WONG and J. P. LONG
Journal of Pharmacology and Experimental Therapeutics November 1968, 164 (1) 176-184;
S. WONG
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. P. LONG
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

α,ά-Bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p-diacetylbiphenyl bromide (DMAE) has been found to antagonize the ganglionic stimulating actions of nicotine (NIC), tetramethylammonium bromide (TMA), dimethylphenylpiperazinium iodide (DMPP) and acetylcholine (ACh). Pressor responses to splanchnic nerve stimulation and central vagal nerve stimulation indicated that transmission through ganglia remained unimpaired at levels of DMAE sufficient to block the ganglionic stimulants. NIC was most readily blocked, while KCl and nerve stimulation resisted blockade by DMAE. The sequence of sensitivity to blockade is: NIC > TMA > DMPP > ACh > KC1 and nerve stimulations. The respiratory stimulating action of NIC was completely abolished by DMAE (400 µg/kg). By using the cat nictitating membrane-cervical sympathetic ganglion preparation, the sequence of sensitivity to blockade by DMAE was confirmed, i.e., NIC > TMA > ACh > nerve stimulation. The ED5O for nerve stimulation was estimated to be 1000 times greater than that for NIC. The sequence of sensitivity to blockade by hexamethonium (C6) was also found to be: NIC > TMA > ACh > nerve stimulation. However, the ED5O for nerve stimulation was 50 times greater than that for NIC. Low-frequency (0.1-1.0 cps) stimulations of the cervical sympathetic nerve were completely blocked by C6, whereas single-shock stimulations were potentiated and 1.0-cps stimulations were not affected by DMAE. DMAE is the Only known derivative of the hemicholinium (HC-3) structure that exhibits either catecholamine-potentiating actions or the selective antinicotinic action.

Footnotes

    • Received January 19, 1968.
    • Accepted June 10, 1968.
  • © 1968, by The Williams & Wilkins Company

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 164, Issue 1
1 Nov 1968
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
ANTAGONISM OF GANGLIONIC STIMULANTS BY α,ά-BIS-(DIMETHYLAMMONIUMACETALDEHYDE DIETHYLACETAL)-p,p''-DIACETYLBIPHENYL BROMIDE (DMAE)
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

ANTAGONISM OF GANGLIONIC STIMULANTS BY α,ά-BIS-(DIMETHYLAMMONIUMACETALDEHYDE DIETHYLACETAL)-p,p''-DIACETYLBIPHENYL BROMIDE (DMAE)

S. WONG and J. P. LONG
Journal of Pharmacology and Experimental Therapeutics November 1, 1968, 164 (1) 176-184;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

ANTAGONISM OF GANGLIONIC STIMULANTS BY α,ά-BIS-(DIMETHYLAMMONIUMACETALDEHYDE DIETHYLACETAL)-p,p''-DIACETYLBIPHENYL BROMIDE (DMAE)

S. WONG and J. P. LONG
Journal of Pharmacology and Experimental Therapeutics November 1, 1968, 164 (1) 176-184;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics