Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

ORAL EFFECTIVENESS OF BETA ADRENERGIC ANTAGONISTS IN PREVENTING EPINEPHRINE-INDUCED METABOLIC RESPONSES

J. H. BROWN, D. A. RIGGILO and K. W. DUNGAN
Journal of Pharmacology and Experimental Therapeutics September 1968, 163 (1) 25-35;
J. H. BROWN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. A. RIGGILO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. W. DUNGAN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Studies were directed to measurement of hyperlactic acidemia and hyperglycemia induced by various catecholamines in anesthetized rats and conscious dogs. A family of compounds structurally related to the beta adrenergic blocking agent sotalol (MJ 1999) was investigated for potency with respect to inhibition of the aforementioned metabolic responses. Data were correlated with attenuation of isoproterenol-induced relaxation of isolated guinea-pig tracheal smooth muscle. Increasing the alkyl chain length of the p-alkylsulfonamido moiety on the benzene ring reduced beta adrenergic blocking activity, as did increasing the size of the N-alkyl group on the amino nitrogen up to n-heptyl. Branched N-alkyl groups (e.g., sec.-and tert.-butyl) increased potency. Alpha,. alkyl substitution of the ethanol moiety variably enhanced or lessened beta blocking activity. For the series of compounds, in general, diminution of epinephrine-induced metabolic responses in vivo correlated well with antagonism of isoproterenol-induced relaxation of smooth muscle in vitro. The hyperlactic acidemia response was consistently more sensitive to attenuation (5- to 20-fold) than was the hyperglycemic response.

Footnotes

    • Received March 4, 1968.
    • Accepted May 21, 1968.
  • © 1968, by The Williams & Wilkins Company

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 163, Issue 1
1 Sep 1968
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
ORAL EFFECTIVENESS OF BETA ADRENERGIC ANTAGONISTS IN PREVENTING EPINEPHRINE-INDUCED METABOLIC RESPONSES
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

ORAL EFFECTIVENESS OF BETA ADRENERGIC ANTAGONISTS IN PREVENTING EPINEPHRINE-INDUCED METABOLIC RESPONSES

J. H. BROWN, D. A. RIGGILO and K. W. DUNGAN
Journal of Pharmacology and Experimental Therapeutics September 1, 1968, 163 (1) 25-35;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

ORAL EFFECTIVENESS OF BETA ADRENERGIC ANTAGONISTS IN PREVENTING EPINEPHRINE-INDUCED METABOLIC RESPONSES

J. H. BROWN, D. A. RIGGILO and K. W. DUNGAN
Journal of Pharmacology and Experimental Therapeutics September 1, 1968, 163 (1) 25-35;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and Sedative-Hypnotics
  • Use-Dependent ‘Agonist’ Effect of Azimilide on the HERG Channel
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics