Abstract
Renal pathways for excretion of monomethylhydrazine (MMH) have been studied by standard clearance methods. The renal handling of this substance is quite similar to that of hydrazine, its parent base. MMH is excreted by a combination of glomerular ifitration, passive diffusion-mediated reabsorption and simultaneous tubular secretion. The secretion process has a limited capacity for MMH transfer and can be inhibited by 2, 4-dinitrophenol. The percentage of the filtered load of MMH excreted is influenced by urine pH. It approximates 100% below pH 6.5 and falls to 20% above pH 7.
Footnotes
- Received June 26, 1967.
- Accepted April 8, 1968.
- © 1968, by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement