Abstract
The effect of chronic morphine treatment on urine formation was studied in rats. In contrast to its acute antidiuretic effect, chronic administration of morphine caused an increase in urinary volume, with an augmentation of solute excretion. This solute diuresis was due, in part, to increased urinary sodium, potassium, phosphate and calcium, but the augmentation of urea excretion was mainly responsible. The increase in urinary volume was partially blocked by nalorphine, with similar antagonistic effects on calcium and urea excretion. These observations may serve to explain the tolerance to the antidiuretic effect of morphine.
Footnotes
- Received February 22, 1968.
- Accepted March 28, 1968.
- © 1968 by The Williams & Wilkins Co.
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