Abstract
In the pithed rat, blood pressure responses to norepinephrine were increased after cocaine and desipramine injections and to a lesser extent during angiotensin infusions. Blood pressure responses to phenylephrine and AHR-602 (a ganglion-stimulating agent) were potentiated by desipramine. Blood pressure responses to phenylephrine and AHR-602 were only slightly influenced by cocaine and angiotensin. Desipramine and cocaine significantly inhibited blood pressure responses to tyramine whereas these responses were unchanged during angiotensin infusions. The total radioactivity recoverable from heart and spleen after norepinephrine-H3 injection was significantly inhibited by cocaine and desipramine but not by angiotensin. These data support the contention that norepinephrine-angiotensin interactions do not involve sympathetic nerve uptake mechanism(s).
Footnotes
- Received December 27, 1967.
- Accepted March 7, 1968.
- © 1968, by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|