Abstract
After rats are treated acutely with chlorpromazine, there is an elevation in the level of i.v. administered H3-melatonin in brain and blood. This effect is not the result of the hypothermia produced by chlorpromazine. Other phenothiazines, such as promazine and promethazine, also elevate tissue H3-melatonin. Chlorpromazine has no effect on the level of H3-melatonin when the indole is administered to rats by injection into the lateral cerebral ventricle. Chlorpromazine inhibits the in vitro metabolism of H3-melatonin by liver slices, suggesting that the drug alters the tissue levels of the indole by slowing its metabolism. Chronic treatment with phenobarbital causes a decreased H3-melatonin concentration in the brain 30 min after i.v. injection of the indole.
Footnotes
- Received November 27, 1967.
- Accepted February 9, 1968.
- © 1968 by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
In this issue
INHIBITION OF THE METABOLISM OF H3-MELATONIN BY PHENOTHIAZINES
