Abstract

Hydrazine a weakly basic amine chemically related to ammonia, is a diuretic agent that increases renal excretion of sodium, potassium and water when given i.v. to dogs. Increased excretion of sodium is due to a fall in net tubular reabsorption, whereas increased potassium excretion may result from a combination of augmented delivery of sodium to the distal tubule and direct stimulation of potassium secretion. Selective infusion of hydrazine into one renal artery results in an ipsilateral diuresis of sodium and water, indicating that these effects reflect a direct renal action.