Abstract
Antihistamines, in general, inhibit the formaldehyde-induced inflammatory response in the hind paws of rats. This inhibition is not antagonized by sotalol (MJ 1999), a beta adrenergic blocking agent. Catecholamines, which also inhibit the inflammatory response, are blocked by sotalol in this regard. Antiinflammatory activity of the antihistamines does not correlate well with antihistaminic activity per se, antiserotonin activity or local anesthetic activity, thus suggesting a nonspecific mode of action for these drugs. Possible mechanisms of action are discussed.
Footnotes
- Received October 3, 1967.
- Accepted November 17, 1967.
- © 1968 by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement