Abstract
The rates of absorption, metabolism and excretion of thalidomide were compared in rabbits and rats. The half-life of the drug was virtually the same (2-3 hr) in rats, rabbits and pH 7.4 buffer. The absorption of orally administered thalidomide was more rapid in rabbits than in rats and the time-course for the elimination of metabolites was different in the two species. Although thalidomide is metabolized mainly by spontaneous hydrolysis in various tissues, the rate of breakdown is considerably greater in rabbit liver. Evidence is presented indicating that thalidomide in both species becomes bound to tissue components, possibly by covalent bonds.
Footnotes
- Received June 21, 1967.
- Accepted October 25, 1967.
- © 1968 by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement