Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

PREVENTION OF VENTRICULAR FIBRILLATION DURING INDUCED HYPOTHERMIA BY N, N-DIISOPROPYL-N'-ISOAMYL-N'-DIETHYLAMINOETHYLUREA (P-286)

C. Richard Bennett, Harold H. Smookler and Joseph P. Buckley
Journal of Pharmacology and Experimental Therapeutics January 1968, 159 (1) 115-122;
C. Richard Bennett
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harold H. Smookler
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph P. Buckley
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The adrenal medulla was found to play a significant role in the production of spontaneous ventricular fibrillation occurring during induced hypothermia in dogs. Adrenal venous blood epinephrine levels and myocardial epinephrine content were found to be increased markedly at a temperature which coincided with the production of ventricular fibrillation (22°C). This increase in the epinephrine output from the adrenal medulla was shown to be a neurally mediated phenomenon. Control animals died of ventricular fibrillation at 21.4 ± 028°C, whereas those treated with N, N-diisopropyl-N'-isoamyl-N'-diethylaminoethylurea (P-286) died in cardiac asystole at 11.1 ± 0.75°C. P-286 was found to prevent any increase in myocardial and adrenal venous blood epinephrine content occurring during hypothermia and also appeared to possess direct antiarrhythmic and antifibrillatory properties. P-286 appears to prevent ventricular fibrillation during hypothermia in dogs because of its direct antiarrhythmic and antifibrillatory properties and because it prevents the release of epinephrine from the adrenal medulla.

Footnotes

    • Received May 15, 1967.
    • Accepted August 22, 1967.
  • © 1968 by The Williams & Wilkins Company

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 159, Issue 1
1 Jan 1968
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
PREVENTION OF VENTRICULAR FIBRILLATION DURING INDUCED HYPOTHERMIA BY N, N-DIISOPROPYL-N'-ISOAMYL-N'-DIETHYLAMINOETHYLUREA (P-286)
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

PREVENTION OF VENTRICULAR FIBRILLATION DURING INDUCED HYPOTHERMIA BY N, N-DIISOPROPYL-N'-ISOAMYL-N'-DIETHYLAMINOETHYLUREA (P-286)

C. Richard Bennett, Harold H. Smookler and Joseph P. Buckley
Journal of Pharmacology and Experimental Therapeutics January 1, 1968, 159 (1) 115-122;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

PREVENTION OF VENTRICULAR FIBRILLATION DURING INDUCED HYPOTHERMIA BY N, N-DIISOPROPYL-N'-ISOAMYL-N'-DIETHYLAMINOETHYLUREA (P-286)

C. Richard Bennett, Harold H. Smookler and Joseph P. Buckley
Journal of Pharmacology and Experimental Therapeutics January 1, 1968, 159 (1) 115-122;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
  • Powerful Activation of Skeletal Muscle Actomyosin ATPase by Goniodomin A Is Highly Sensitive to Troponin/Tropomyosin Complex
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics