Abstract
The endogenous stores of norepinephrine, dopamine and 5-hydroxytryptamine in the rabbit brainstem have been manipulated through the use of α-methyl-m-tyrosine, reserpine and pargyline. The changes in amine levels were estimated by fluorometric assay. The rabbits’ core temperatures were monitored during drug treatment and it was found that increases in temperature were correlated with increases in 5-hydroxytryptamine and dopamine while norepinephrine was implicated as an antagonist of temperature increases. Feldberg and Meyers have proposed that temperature regulation results from a balance between the hyperthermic effects of 5-hydroxytryptamine and the hypothermic effects of norepinephrine in the hypothalamus. The experiments reported here support this hypothesis.
Footnotes
- Received September 19, 1966.
- Accepted July 5, 1967.
- © 1967 by The Williams & Wilkins Company
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