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Research ArticleArticle

INSULIN STIMULATION OF LACTATE OXIDATION AND INCORPORATION INTO GLYCOGEN IN FROG SKELETAL MUSCLE

D. R. H. Gourley and Tae Kyu Suh
Journal of Pharmacology and Experimental Therapeutics August 1967, 157 (2) 371-380;
D. R. H. Gourley
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Tae Kyu Suh
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Abstract

The stimulation of time oxidative metabolism of frog muscle by insulin in vitro has been confirmed and its mechanism further explored in the sartorius muscle at 24°C. The oxygen consumption stimulation occurred even in the absence of added substrates and was proportional to the logarithm of the insulin concentration in the range of 0.05 to 50 mU/ml. The effect of insulin on oxygen consumption varied seasonally and was greatest in muscles from summer frogs in which the glycogen content was minimal. The addition of lactate alone also increased the consumption of oxygen, and time extra oxygen consumed in the presence of lactate was significantly increased by insulin. The increase was at least partly a result of a stimulation of the oxidation of the added lactate-1-C14 as determined by the recovery of C14O2, but calculations indicate that insulin also stimulated the oxidation of endogenous substances. Insulin stimulated time incorporation of labeled lactate into muscle glycogen, but a net increase in the glycogen content of insulin-treated muscles was not found.

Footnotes

    • Received June 13, 1966.
    • Accepted March 17, 1967.
  • © 1967 by The Williams & Wilkins Company

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Journal of Pharmacology and Experimental Therapeutics
Vol. 157, Issue 2
1 Aug 1967
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Research ArticleArticle

INSULIN STIMULATION OF LACTATE OXIDATION AND INCORPORATION INTO GLYCOGEN IN FROG SKELETAL MUSCLE

D. R. H. Gourley and Tae Kyu Suh
Journal of Pharmacology and Experimental Therapeutics August 1, 1967, 157 (2) 371-380;

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Research ArticleArticle

INSULIN STIMULATION OF LACTATE OXIDATION AND INCORPORATION INTO GLYCOGEN IN FROG SKELETAL MUSCLE

D. R. H. Gourley and Tae Kyu Suh
Journal of Pharmacology and Experimental Therapeutics August 1, 1967, 157 (2) 371-380;
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