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Research ArticleArticle

STERIC ASPECTS OF ADRENERGIC DRUGS. VI. BETA ADRENERGIC EFFECTS OF EPHEDRINE ISOMERS

A. Tye, R. Baldesberger, J. B. Lapidus and P. N. Patil
Journal of Pharmacology and Experimental Therapeutics August 1967, 157 (2) 356-362;
A. Tye
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R. Baldesberger
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J. B. Lapidus
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P. N. Patil
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Abstract

The effects of the ephedrine isomers were studied in the isolated guinea-pig tracheal chain preparation (which is believed to contain only beta adrenergic receptors). Cumulative dose-response curves were determined in the presence of methacholine-induced tone. The relaxation produced by the isomers was converted into percentage values with maximal effect as produced by isoproterenol or papaverine considered as 100%. In the normal preparation the isomers showed no striking differences in potency, although L(+)- ephednine was the least potent. In preparations from reserpine-pretreated animals (5 mg/ kg i.p., 16-24 hr) the effects of the D(-) isomers were not reduced but the effects of the L(+) isomers were. In similar preparations propranolol reduced the effects of all isomers. The results indicate that in the guinea-pig trachea D(-)-ephedrine and D(-)-pseudo-ephedrine are essentially directly acting drugs, whereas L(+)-ephedrine and L(+)-pseudo-ephedrine possess an appreciable indirect component in their action and that all four isomers probably act at beta adrenergic receptors.

Footnotes

    • Received January 5, 1967.
    • Accepted March 16, 1967.
  • © 1967 by The Williams & Wilkins Company

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Journal of Pharmacology and Experimental Therapeutics
Vol. 157, Issue 2
1 Aug 1967
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Research ArticleArticle

STERIC ASPECTS OF ADRENERGIC DRUGS. VI. BETA ADRENERGIC EFFECTS OF EPHEDRINE ISOMERS

A. Tye, R. Baldesberger, J. B. Lapidus and P. N. Patil
Journal of Pharmacology and Experimental Therapeutics August 1, 1967, 157 (2) 356-362;

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Research ArticleArticle

STERIC ASPECTS OF ADRENERGIC DRUGS. VI. BETA ADRENERGIC EFFECTS OF EPHEDRINE ISOMERS

A. Tye, R. Baldesberger, J. B. Lapidus and P. N. Patil
Journal of Pharmacology and Experimental Therapeutics August 1, 1967, 157 (2) 356-362;
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