Abstract
5-Hydroxytryptamine added to Ringer's solution bathing the corium side of the isolated short-circuited skin of Rana pipiens caused a significant increase in sodium transport across the skin. Doses of 40 µg/ml (9.8 x 10-5 M) and 20 µg/ml (4.9 x 10-5 M) added to the corium side produced a significant (P < .01) increase in sodium transport, whereas 40 µg/ml added to the solution bathing the epidermal side of the skin produced no significant difference in sodium transport. The validity of the short-circuit method in our hands was confirmed by the use of Na22. Creatinine sulfate (1 x 10-4 and 1 x 10-5 M) added to the corium side produced no increase in the rate of sodium transport.
Footnotes
- Received September 17, 1965.
- Accepted August 11, 1966.
- © 1967 by The Williams & Wilkins Company
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