Abstract
Dimethyl sulfoxide (DMSO) added to the external bathing solution of isolated frog skin causes a decrease in electrical potential difference and an increase in conductance but little change in short-circuit current. The permeability of the skin to mannitol, urea, sodium, potassium and chloride is increased by DMSO but the rate of net active Na transport is not changed markedly. The effects appear to be mainly the result of changes in osmotic activity of the bathing solution since they are similar to the effects caused by urea in similar concentrations.
Footnotes
- Received April 13, 1966.
- Accepted May 24, 1966.
- © 1966 by The Williams & Wilkins Company
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