Abstract
A radiometric method for measuring the paw temperature of unanesthetized rats is described. It is a simple and accurate means for measuring the paw temperature changes during experimental pedal inflammation induced by the subplantar injection of phlogistic agents. The method may be used as a supplement to other methods for the evaluation of the antiinflammatory activity of drugs. The paw temperature profile resulting from the subplantar injection of yeast shows two peaks, an initial rise followed by a more pronounced rise. Aspirin partially inhibits the initial temperature rise, and greatly suppresses the second. Chlorprophenpyridamine maleate is more effective than aspirin in suppressing the initial temperature rise, but has less inhibitory effect on the delayed response.
Footnotes
- Received March 24, 1966.
- Accepted April 25, 1966.
- © 1966 by The Williams & Wilkins Company
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RADIOMETRIC MEASUREMENT OF PAW TEMPERATURE CHANGES ASSOCIATED WITH LOCAL INFLAMMATION
