Abstract
The chronotropic effect of 17 amino acids was studied by direct perfusion of the sinus node through its nutrient artery in vivo in the dog. Fourteen of the amino acids had no significant chronotropic effect; that of histidine was only weakly negative. Aspartic acid and glutamic acid both produced a negative chronotropic effect which appears to be due to a direct action on the sinus node, has no cholinergic or antiadrenergic component, and is not pH-dependent.
Footnotes
- Accepted March 4, 1966.
- The Williams & Wilkins Comapny
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