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Research ArticleArticle

PARTICIPATION OF A CNS-THYROID NEURAL PATHWAY IN EPINEPHRINE-INDUCED HYPERGLYCEMIA IN THE CAT

Louis P. Gangarosa and Victor Distefano
Journal of Pharmacology and Experimental Therapeutics May 1966, 152 (2) 325-331;
Louis P. Gangarosa
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Victor Distefano
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Abstract

Two successive doses of epinephrine injected into normal or sham-operated cats evoked similar increases in blood glucose. Hyperglycemic responses to epinephrine (EHG) were attenuated in high spinal cats, thus verifying results reported previously. This observation is best explained by assuming an interruption of an epinephrine-activated hyperglycemic neural pathway to the periphery. Since high thoracic spinal section, bilateral thoracocervical sympathectomy, thyroid denervation and thyroidectomy attenuated the EHG, it is postulated that the hyperglycemic pathway emerges from the spinal cord high in the thoracic region, ascends in the sympathetic chain and innervates the thyroid gland. Attenuated epinephrine-induced hyperglycemia was not noted after low thoracic spinal cord section (below T4), pancreatectomy, hepatic denervation or hypophysectomy. Occlusion of the thyroid vein attenuated by EHG, suggesting the release of a thyroid hyperglycemic factor.

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    • Accepted November 10, 1965.
  • The Williams & Wilkins Comapny

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Journal of Pharmacology and Experimental Therapeutics
Vol. 152, Issue 2
1 May 1966
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Research ArticleArticle

PARTICIPATION OF A CNS-THYROID NEURAL PATHWAY IN EPINEPHRINE-INDUCED HYPERGLYCEMIA IN THE CAT

Louis P. Gangarosa and Victor Distefano
Journal of Pharmacology and Experimental Therapeutics May 1, 1966, 152 (2) 325-331;

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Research ArticleArticle

PARTICIPATION OF A CNS-THYROID NEURAL PATHWAY IN EPINEPHRINE-INDUCED HYPERGLYCEMIA IN THE CAT

Louis P. Gangarosa and Victor Distefano
Journal of Pharmacology and Experimental Therapeutics May 1, 1966, 152 (2) 325-331;
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