Abstract
β- Heptamethyleniminoethylaminoguanidine sulfate, EX 4891A, has been shown to be a potent hypotensive agent in the anesthetized rat, cat and dog and in the unanesthetized renal hypertensive dog. This compound was found to have a short-term direct vasodilator effect in the denervated hind limb of the dog. Interference with sympathetic neuronal activity was found in both the in vivo nictitating membrane-superior cervical ganglion preparation in cats and the in vitro isolated innervated rabbit ileum preparation. Cross-circulation studies in dogs indicated a lack of a centrally mediated hypotensive effect. EX 4891A depleted catecholamines from the rat ventricle but did not exhibit a sympathomimetic effect due to an acute release of catecholamines in active forms.
Footnotes
- Accepted November 1, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|