Abstract
The effect of various parasympathomimetic and other drugs on brain monophosphoinositide turnover was studied in vivo. Parathion increased brain acetylcholine levels by 95% and produced a concomitant increase of 29% in brain monophosphoinositide turnover. Pilocarpine in doses of 2 mg/kg or greater increased monophosphoinositide turnover by 38%. This effect of pilocarpine was abolished by pretreatment with the atropine, which by itself had no effect on monophosphoinositide turnover. Amphetamine did not increase monophophoinositide turnover, and peripheral cholinergic stimulation produced by bethanechol was also without effect. Pentobarbital was found to decrease monophosphoinositide turnover by 21% in the presence of a 28% increase in brain acetylcholine levels. These results demonstrate that central cholinergic stimulation in rats is accompanied by an increase in brain monophosphoinositide turnover in vivo. This effect appears to be of a specifically cholinergic nature.
Footnotes
- Accepted August 18, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|